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Third, there is marked heterogeneity in IF protocolsincluding variations in fasting duration, feeding windows, and participant characteristicscomplicating direct comparisons across studies and meta-analyses [15, 17,18,19]

Despite the availability of multiple chemotherapeutic options, clinical efficacy remains limited due to poor drug solubility, restricted intestinal absorption, rapid systemic clearance, and multidrug resistance

We found that although -lactam antibiotics, such as MEM, AMP, and CAZ, exhibit potent antibacterial properties, they concurrently induce significant oxidative damage to bacterial DNA and RNA

Nevertheless, knockout of p53 or p21 paradoxically accelerates gastrointestinal damage and death, indicating that p53 may have a bidirectional effect in radiation-induced injury (198)

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